VARIANTS OF SHIGELLA FLEXNERI SENSITIVE TO NEOCARZINOSTATIN AND ACTINOMYCIN D

Multidrug-Resistant Atypical Variants of Shigella flexneri in China

We identified 3 atypical Shigella flexneri varieties in China, including 92 strains with multidrug resistance, distinct pulse types, and a novel sequence type. Atypical varieties were prevalent mainly in developed regions, and 1 variant has become the dominant Shigella spp. serotype in China. Improved surveillance will help guide the prevention and control of shigellosis.

Keratitis due to Shigella flexneri.

Multiresistant Shigella flexneri isolates were cultured from the cornea and stool of a girl. Genetic analysis showed the isolates were identical. Shigella spp. are rare causes of ulcerative keratitis; there have only been 14 published cases since 1943. Although prognosis after local treatment is good, shigellosis is a systemic infection, possibly leading to dehydration.

Highly sensitive detection of Shigella flexneri using fluorescent silica nanoparticles.

Robust signal amplification tactic is a good solution for improving detection sensitivity. Unprocessed fluorophores have many limitations. Here we describe an effective strategy for highly sensitive detection of bacteria by using fluorescent conjugated nanoparticles. The nanoparticles were synthesized using silica as matrix. Fluorescein isothiocyanate distributed in the matrix. S. flexneri spec...

T-lymphocyte clones responsive to Shigella flexneri.

T lymphocytes from a patient with Shigella flexneri dysentery and postdysenteric reactive arthritis were cloned by limiting dilution with recombinant interleukin-2 and a strain of S. flexneri different from that which had infected her. Five of eight clones produced proliferated in response to the shigellae used to generate the clones. The response required irradiated syngeneic blood mononuclear...

Fulminating encephalopathy and Shigella flexneri infection.